Unruptured epidermal cysts, correspondingly, are characterized by arborizing telangiectasia, whereas ruptured epidermal cysts present with peripheral, linear, branched vessels (45). Steatocystoma multiplex and milia, as described in reference (5), share common dermoscopic traits, including a peripheral brown rim, linear vessels, and a consistent yellow background across the entire lesion. Significantly, while other mentioned cystic lesions display linear vessels, pilonidal cysts are distinguished by the presence of dotted, glomerular, and hairpin-shaped vessels. Pilonidal cyst disease, amelanotic melanoma, basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, lymphoma, and pseudolymphoma should be part of the differential diagnostic evaluation for pink nodular lesions (3). Based on our clinical observations and two referenced cases, a pink backdrop, central ulceration, peripheral dotted vessel arrangement, and white lines appear to be frequent dermoscopic indicators of pilonidal cyst disease. Dermoscopic characteristics of pilonidal cyst disease, as observed by us, include central yellowish, structureless areas in conjunction with peripheral hairpin and glomerular vessels. Overall, the dermoscopic attributes previously discussed successfully differentiate pilonidal cysts from other skin tumors, and dermoscopy provides substantial support to clinical diagnoses in cases where pilonidal cysts are suspected. To more thoroughly characterize the typical dermoscopic signs of this disease and their frequency, additional research is required.
Esteemed Editor, segmental Darier disease (DD) stands as a rare medical condition, with approximately forty documented instances referenced in English-language publications. Researchers hypothesize that the presence of a post-zygotic somatic mutation in the calcium ATPase pump, exclusively in lesional skin, may contribute to the development of the disease. Lesions in segmental DD type 1 are unilateral and follow Blaschko's lines, a pattern distinct from segmental DD type 2, which features concentrated areas of heightened severity in patients with generalized DD (1). Precise diagnosis of type 1 segmental DD is impeded by the absence of a positive family history, the late presentation of the disease typically in the third or fourth decade, and the lack of recognizable features linked to DD. The differential diagnosis of type 1 segmental DD includes acquired papular dermatoses with linear or zosteriform distributions, such as lichen planus, psoriasis, lichen striatus, or linear porokeratosis (2). In this report, we present two cases of segmental DD, the first being a 43-year-old female who had suffered from pruritic skin alterations for five years, with symptoms worsening during specific seasons. A swirling pattern of light brownish to reddish keratotic small papules was observed on the left abdomen and inframammary area during the examination (Figure 1a). Figure 1b highlights dermoscopic findings: polygonal or roundish yellowish-brown areas, surrounded by whitish, structureless tissue. Pathologic downstaging Dermoscopic brownish polygonal or round areas are histopathologically associated with hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes, a finding confirmed by the biopsy specimen (Figure 1, c). Figure 1(d) showcases the notable improvement observed in the patient following the prescription of 0.1% tretinoin gel. The second case involved a 62-year-old female patient who presented with small, red-brown papules, eroded papules, and yellowish crusts arranged in a zosteriform pattern on the right upper abdomen (Figure 2a). Dermoscopy revealed yellowish, polygonal, and roundish areas surrounded by a structureless field of whitish and reddish discoloration (Figure 2, panel b). Histological findings indicated the presence of compact orthokeratosis, along with scattered small parakeratosis foci, a distinctive granular layer containing dyskeratotic keratinocytes, and acantholytic foci above the basal layer, all pointing to a diagnosis of DD (Figure 2, d, d). The patient's condition improved after being prescribed topical steroid cream and 0.1% adapalene cream. A diagnosis of type 1 segmental DD was established in both cases through the combination of clinical and histopathological information; the histopathology report could not definitively exclude acantholytic dyskeratotic epidermal nevus, which presents identically to segmental DD both clinically and microscopically. The diagnosis of segmental DD was bolstered by the late emergence and worsening influenced by external factors, including heat, sunlight, and perspiration. Although clinico-histopathological concurrence is the standard for confirming a type 1 segmental DD diagnosis, dermoscopy serves as a potent adjunct, clarifying the diagnosis by distinguishing it from other possible conditions and their respective dermoscopic manifestations.
The urethra is infrequently affected by condyloma acuminatum, and when present, it's predominantly located in the most distal segment. Urethral condylomas have been addressed by a variety of treatment approaches. Extensive and variable treatments encompass laser therapy, electrosurgical procedures, cryotherapy, and topical applications of cytotoxic agents like 80% trichloroacetic acid, 5-fluorouracil cream (5-FU), podophyllin, podophyllotoxin, and imiquimod. The treatment of intraurethral condylomata is typically performed using laser therapy. In a case study of a 25-year-old male patient with meatal intraurethral warts, 5-FU treatment was effective, overcoming previous failures with laser therapy, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid applications.
Ichthyoses, a diverse collection of skin disorders, are recognized by their characteristic erythroderma and generalized scaling. The nature of the connection between ichthyosis and melanoma remains poorly understood. We report a singular instance of acral melanoma of the palm in a senior patient with co-existing congenital ichthyosis vulgaris. The biopsy confirmed a melanoma exhibiting ulceration and superficial spread. So far, our records indicate no reports of acral melanomas in individuals presenting with congenital ichthyosis. Undeniably, the probability of melanoma invasion and metastasis demands that patients diagnosed with ichthyosis vulgaris adhere to a schedule of regular clinical and dermatoscopic screenings.
A 55-year-old male, the subject of this report, was found to have penile squamous cell carcinoma (SCC). 2-DG datasheet The patient's penis housed a mass, incrementally expanding in size. Through the surgical procedure of a partial penectomy, we removed the mass. The histologic evaluation revealed the presence of a well-differentiated squamous cell carcinoma. The polymerase chain reaction process identified human papillomavirus (HPV) DNA. HPV type 58 was discovered in a squamous cell carcinoma sample by means of sequencing analysis.
The presence of both cutaneous and extracutaneous features is a prevalent observation in various genetic syndromes, extensively documented. However, there might yet be undiscovered patterns of symptoms that have not been cataloged. British ex-Armed Forces In this case report, we detail a patient's experience with multiple basal cell carcinomas originating from a nevus sebaceous, leading to their admission to the Dermatology Department. The cutaneous malignancies were further compounded by the patient's palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar abnormalities, a uterine myoma, an ovarian cyst, and a highly dysplastic colon adenoma. A combination of multiple disorders could be indicative of a genetic predisposition for the illnesses.
The inflammation of small blood vessels, a consequence of drug exposure, results in drug-induced vasculitis, potentially leading to damage in the affected tissue. Rare instances of drug-induced vasculitis are documented in the literature, particularly those related to chemotherapy treatments, or in conjunction with radiation therapy. Our patient's diagnosis revealed small cell lung cancer (SCLC), categorized as stage IIIA (cT4N1M0). The second cycle of carboplatin and etoposide (CE) chemotherapy, administered four weeks prior, was accompanied by the emergence of cutaneous vasculitis and rash, particularly on the patient's lower extremities. CE chemotherapy was ceased, and symptomatic relief was provided through methylprednisolone administration. Patients on a course of prescribed corticosteroids experienced an amelioration of the local condition. After the chemo-radiotherapy course was finished, the patient continued with four cycles of consolidation chemotherapy containing cisplatin for a total of six cycles. The cutaneous vasculitis showed a further reduction, as verified by clinical examination. Completion of the consolidation chemotherapy treatment was followed by the performance of elective brain radiotherapy. Until the disease returned, the patient was monitored clinically. The platinum-resistant disease prompted the administration of additional chemotherapy treatments. The patient succumbed to their illness seventeen months after being diagnosed with SCLC. To our knowledge, this is the initial documented instance of a patient experiencing vasculitis in their lower limbs concurrent with radiotherapy and CE chemotherapy administered as part of the initial treatment protocol for SCLC.
Traditionally, (meth)acrylates-induced allergic contact dermatitis (ACD) afflicts dentists, printers, and fiberglass workers in the occupational setting. The deployment of artificial nails has been associated with documented instances of problems affecting both nail technicians and clients who utilize them. ACD, a consequence of (meth)acrylates in artificial nails, is a prevalent issue affecting both nail technicians and consumers. Severe hand dermatitis, especially on the fingertips, coupled with frequent facial dermatitis, emerged in a 34-year-old woman who had been working in a nail art salon for two years. The patient's nails, frequently splitting, led to a four-month use of artificial nails, necessitating regular gel applications for their care. Multiple instances of asthma were reported by her during her presence at her place of work. To establish a baseline, a patch test was applied to the baseline series, the acrylate series, and the patient's own material.